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It is produced in Germany from Vanuatu-grown kava. The roots are the part traditionally used in Polenesia. This extract is very potent. For stronger more pronounced effects take 2-3 times that amount. This should be swallowed and washed down with some water.
As of 2011 there have been no formal clinical trials performed to study the efficacy or safetyof kratom to treat opioid addiction. The pharmacological effects of kratom on humans are not well studied. Its metabolic half-life protein binding Opms Kratom Liquid Dose and elimination characteristics are all unknown. Kratom does not appear to have significant adverse effects and in particular appears not to cause the hypoventilation typical of other opioids. Compulsive use has been reported among drug users who inject opioids and those who use opioids to manage pain without direction from medical professionals. Side effects associated with chronic kratom use include loss of appetite and weight loss constipation and darkening of the skin color of the face. Chronic use has been associated with bowel obstruction.